Phyllanthus niruri

HEPATOPROTECTIVES, LIVER TONIC, ANTI HEPATOTOXIC

Phyllanthus niruri
Bhuiamalaki, botanically known has Phyllanthus niruri is a member of Euphorbiaceae family. The decoction of the plant has historically being used in jaundice. In a preliminary study, carriers of hepatitis B virus were treated with a preparation of the plant Phyllanthus niruri for 30 days. 22 of 37 (59%) treated patients had lost hepatitis B surface antigen when tested 15-20 days after the end of the treatment compared with only 1 of 23 (4%) placebo-treated controls. Some subjects have been followed for up to 9 months. In no case has the surface antigen returned. Studies also revealed that Phyllanthus niruri exhibits antiviral actions on Hepatitis B in human subjects and in vitro.
Preclinical studies demonstrates that an extract of the Phyllanthus niruri plant inhibits endogenous DNA polymerase of hepatitis B virus and binds to the surface antigen of hepatitis B virus. Extracts of Phyllanthus niruri have been shown to exert hepatoprotective effect against carbon tetrachloride induced liver cell damage in rabbits. Pre-treatment with extract of Phyllanthus niruri, reduced paracetamol-induced acute liver damage in rats as monitored by estimating the serum transaminases (SGOT and SGPT), bilirubin and histopathological changes in the livers.

Withania somnifera

HEPATOPROTECTIVE AGENTS, LIVER TONIC, ANTI HEPATOTOXICWithania somnifera

Withania somnifera (L) Dunal (Solanaceae), commonly called Ashwagandha (Sanskrit) is an Ayurvedic Indian medicinal plant, which has been widely used as a home remedy for several ailments.
Mechanism by which the W. somnifera exerts a hepatoprotective effect in a hyperammonemic condition could be attributed to (i) presence of natural antioxidants, (ii) its free radical scavenging and antioxidant properties and (iii) excess removal of urea related compounds. The exact underlying mechanism is still unclear and further research is needed.

Boerhavia diffusa

HEPATOPROTECTIVE AGENTS, LIVER TONIC, ANTI HEPATOTOXICBoerhavia diffusa

The roots of Boerhavia diffusa, commonly known as 'Punarnava', are used by a large number of tribes in India for the treatment of various hepatic disorders and for interna inflammation. Anodectal data has lso reported effectiveness of Boerhavia diffusa incases of oedema and ascites resulting from early cirrhosis of the liver and chronic peritonitis. . A proprietory hepatotonic herbal formulation containing Boerhavia diffusa as one of the major ingredient offered significant protection against decrease in haemoglobin percentage R.B.C. and W.B.C counts and the various liver microsomal enzymes.