Tinospora cordifolia

HEPATOPROTECTIVE AGENTS, LIVER TONIC, ANTI HEPATOTOXIC Tinospora cordifolia

Tinospora cordifolia commonly known as Guduchi is one of the most valuable medicinal herbs of ayurveda. According to the Ayurvedic lexicons Tinospora cordifolia is referred to as 'Amrita'. The term 'Amrita' is attributed to this drug in recognition of its ability to impart youthfulness, vitality and longevity to its patron. In modern medicine it is well known for its hepatoprotective, adaptogenic and immunomodulatory activities.
Kupffer cells are major determinants of outcome of liver injury. Their activity was therefore studied in a model of chronic liver disease. The effect of Tinospora cordifolia, with proven hepatoprotective activity, was evaluated on Kupffer cell function, using carbon clearance test as a parameter. Antihepatotoxic activity of Tinospora cordifolia was studied in albino rats intoxicated with CCl4.
Liver function was assessed based on morphological, biochemical (SGPT, SGOT, Serum alkaline phosphatase, Serum bilirubin) and functional (Pentobarbitone sleep time) tests. Efficacy of Tinospora cordifolia as a sole constituent in goats liver were studied. Results revealed clinical and hematobiochemical improvement at the later stages in Tinospora cordifolia treated goats, indicating that it has got hepatoprotective action

Silybum marianum

HEPATOPROTECTIVE AGENTS, LIVER TONIC, ANTI HEPATOTOXIC

Silybum marianum

Blessed Milk Thistle (Silybum marianum) is a milk thistle, a plant of the Asteraceae family. This fairly typical thistle has red to purple flowers and shiny pale green leaves with white veins. Originally a native of Southern Europe through to Asia, it is now found throughout the world. The medicinal parts of the plant are the ripe seeds.

Its traditional use as a liver tonic has been supported by research showing that it contains constituents that protect liver cells from chemical damage. Historically, this herb has been used in Europe as a liver tonic, and current phytotherapy indicates its use in a whole range of liver and gallbladder conditions, including hepatitis and cirrhosis. It may also have value in the treatment of chronic uterine problems. A wealth of research done in Germany is revealing exciting data about reversal of toxic liver damage, as well as protection from potential hepato-toxic agents.

A study conducted in 85 patients revealed that silybin conjugated with vitamin E and phospholipids could be used as a complementary approach to the treatment of patients with chronic liver damage.

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